Involvement of Brain-Derived Neurotrophic Factor in Late-Life Depression
نویسندگان
چکیده
منابع مشابه
Involvement of Mice Hippocampus Brain-derived Neurotrophic Factor in Diazinon-induced Depressive Behavior in Mice
Background: Diazinon (Dzn), an Organophosphorus (OP) pesticide, is extensively used in agriculture. Acetylcholinesterase inhibition is linked to OP toxicity, and there are major mental health concerns associated with the use of pesticides. The objective of this study was to assess the depressive behavior in an animal model following their exposure to Dzn and the effect on the Brain-Derived Neur...
متن کاملBrain-Derived Neurotrophic Factor for Depression Therapeutics
Increasing evidence over the last two decades has indicated that the pathophysiology of Major Depressive Disorder (MDD) and the action of antidepressants both involve Brain-Derived Neurotrophic Factor (BDNF), a major neuronal growth factor in the brain. MDD is a complex disorder that results from genetic and environmental influences, singly or in combination. This article reviews the current kn...
متن کاملReduced cerebrospinal fluid levels of brain-derived neurotrophic factor is associated with cognitive impairment in late-life major depression.
OBJECTIVES Late-life depression (LLD) is associated with reduced neurotrophic support and abnormalities in neurodegenerative cascades. The aim of the present study is to determine the concentrations of brain-derived neurotrophic factor (BDNF), amyloid-β42, total Tau, and phosphorylated Tau in the cerebrospinal fluid (CSF) of patients with LLD and cognitive impairment compared to healthy older a...
متن کاملCirculating Glial-derived neurotrophic factor is reduced in late-life depression.
BACKGROUND The Glial cell-line derived neurotrophic factor (GDNF) is part of the TGF-β superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. AIM To assess serum GDNF concentration in elderly subjects with late-life depression, before antidepressant treatment, as compared to healthy elderly controls. METH...
متن کاملBrain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: a longitudinal study.
Changes in brain-derived neurotrophic factor (BDNF) level are implicated in the pathophysiology of cognitive decline in depression and neurodegenerative disorders in older adults. We aimed to evaluate the longitudinal association over two years between BDNF and persistent cognitive decline in individuals with remitted late-life depression and Mild Cognitive Impairment (LLD + MCI) compared to ei...
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ژورنال
عنوان ژورنال: The American Journal of Geriatric Psychiatry
سال: 2013
ISSN: 1064-7481
DOI: 10.1016/j.jagp.2012.10.026